Why will get Diabetic nephropathy?

Diabetic nephropathy is mainly caused by primary and secondary lesions (including genetic and environmental factors, the relative or absolute lack of insulin, and resistance to insulin, high blood sugar level and metabolic syndrome), together with the disorders in immune regulation of the body, the blood sugar level will be raised and a series of pathological changes will happen to the glomerular inherent cells.The pathological changes normally lead to thickened glomerular basement membrane and narrowed lumen and blood vessel which cause disorders in blood vessel microcirculation, renal ischemia and hypoxia and damages to the blood capillary around the glomerulus and kidney tubules. Together with further inflammatory infiltration, the renal fibrosis will be triggered. Once the renal fibrosis is triggered, phenotypic switches will occur in the kidney inherent cells, large amount of extracellular matrix will be produced which could replace the healthy kidney inherent cells. With the progression of the condition, glomerular sclerosis and necrosis will come to existence. That’s why we refer it as a disease of diabetic glomerular basement membrane.