2016年10月25日星期二

Prevention of chronic pyelonephritis

慢性肾盂肾炎的预防
增强体质,提高机体防御能力。积极治疗易发因素,如糖尿病、肾结石和尿路梗阻等。减少导尿及泌尿道器械操作。注意外阴清洁。女性的再发与性生活有关者,性生活后即排尿,并口服一次复方磺胺甲噁唑。更年期可服用尼尔雌醇12mg,每月12次,可增强局部抵抗力。

Enhance physical fitness, improve the body's defense capabilities. Actively treat the prone factors such as diabetes, kidney stones and urinary tract obstruction. Reduce catheterization and urinary tract equipment operation. Note the vulva clean. Female recurrence related to sex life, after sexual urination, and take oral compound sulfamethoxazole once. Menopause people can take nylestriol 1 ~ 2mg, 1 or 2 times per month, which can enhance local resistance.

【To walk for 2 minutes after sitting for 1 hour, reduce the risk of early death 】

【坐1小时走2分钟,降低早亡风险】美国研究发现,每坐1小时站起来活动2分钟,能减少死亡风险33%,而对于那些患有慢性肾病的人,甚至能减少41%的死亡风险。研究人员建议,除了起身走动,久坐的人最好每周至少能进行2个小时中等强度的运动。

To walk for 2 minutes after sitting for 1 hour, reduce the risk of early death the United States study found that each 1 hour sitting to stand up for 2 minutes, can reduce 33% of the death risk, and for those with chronic kidney disease, and even can reduce 41% risk of death. The researchers suggest,except gor stand up and walk around, sedentary people best to take moderate intensity exercise at least two hours per week.

【Kidney disease 、uremia patient diet should pay attention to what?】

The diet is basic condition of human life,and to make people live happy and healthy,full of vigor of and wisdom,not only eat satisfied belly,a reasonable allocation must also consider the diet,ensure all the nutrients needed by the human body balance and adequate intake,and can be fully absorbed bu the human body,and dietary characterastic everyone has a large extent influence on our health.
Unscientific eating will induce disease,aggravate the disease,affect the treatment of disease.Patients with kidney disease,especially the case,and many patients with kidney disease often due to the lack of strict diet and variety of complications or increase the severity of the disease.
1.good qaulity low protein.
Excessive protein intake,can increase the burden on the kidneys,so to control the total amount of protein intake.But the protein as the essential nutrients,the body is not the lack of essential of amino acids so that more should be guarentted and the specific implementation should be .Try the reduce the plant protein,containing purine base large.excessive intake will increase the burden on the kidneys,appropriate to add milk,egg,fish,and other animal protein.
2.Low potassium diet.

High potassium is one of the most common complications of

2016年10月23日星期日

Creatinine is a product of muscle metabolism

Creatinine is a product of muscle metabolism, is a toxin excreted by the kidney, if your creatinine level in blood higher than normal value, it means that your kidney function is impaired, as we people get injured ,we can not work anymore. But your condition can be completely cured if you take timely treatment, no need worry too much.
Actually ,creatinine increasing is caused by the renal glomerulus impaired.The glomerulus get injured and become sclerosis ,which lead to the GFR(glomerular filtration rate) reducing and can not filtrate the toxins, so the creatinine stay in blood getting high. As long as the sclerosis glomerulus get repaired ,the filtration function recovered ,the complete renal function will recover, then the creatinine will be excreted out naturally. If you do not take treatment ,day by day ,more and more glomerulus will sclerosis and necrosis, your kidney function will disappear, and the dead glomerulus can not be repaired,your disease can not be treated anymore. Now it is the best time for you to take treatment ,the treatment you need now is repairing your damaged gomerulus and recover kidney function.
Shijiazhuang Kidney Disease Hospital take Chinese Traditional Medicine Therapy,which can clean out all the toxins in blood ,and repair the the damaged glomerulars, and improve kidney function.If kidney function recovered ,creatinine will be excreted out natually

What are factors that can cause chronic pyelonephritis into chronic renal insufficiency?慢性肾盂肾炎患者促使发展为慢性肾功能不全的因素有?

①治疗不彻底的再发性或持续性感染;②肾脏发育不全或畸形;③出现进行性免疫性损害;④高血压肾损害;⑤严重膀胱输尿管返流对肾脏的损害;⑥出现合并感染的肾结石

(1) treatment of incomplete recurrent or persistent infection; 
(2) renal hypoplasia or malformation; 
(3) progressive immune damage; 
(4) hypertension renal damage; 
severe vesicoureteral reflux damage to the kidneys; 
the emergence of kidney stones with infection.

2016年10月20日星期四

The Treating for PKD

Polycystic kidney is large and small cysts in the entire kidney, these cysts will grow with increasing age, which can damage the renal structure and reduce the nephron. Later the damaged kidneys can not support the life and the uremia appears.
These food suitable for PKD patients:
1. The vegetables and fruits rich in vitamin.
2. These food dissolving stones, such as agarics.
3. The food with diuretic effect.
4. Alkaline foods are also taken, which plays a supporting role in the treatment of polycystic kidney.
5. These fruits and vegetables rich in iron, such as carrot.
There are much disadvantages for PKD treating. If the disease can not be cured from the root, the patients are advised to receive Chinese medical treatment. The whole concept of traditional Chinese medicine in the treatment of polycystic kidney can regulate swelling, thus thoroughly cure renal cyst.

多囊肾是整个肾脏长满大大小小的囊肿,那些囊肿会随年龄增大而长大,那样会压迫肾脏,使肾脏的结构受到损害,减少产生尿的肾单位数目,到后来肾脏受损害到不能维持人正常的生命,那时会出现尿毒症。 多囊肾患者适合吃的食物: 1.维生素高的水果蔬菜。 2 中医药中能容石化石的食品,如黑木耳。 3 有利 尿作用的食物。 4.多囊肾饮食呈现 碱 性的食品亦多服用,会起到对多囊肾治疗辅 助作用。 5 含铁丰富的水果蔬菜,如红萝卜等。 对于多囊肾手术治疗弊端太多。治疗不彻底。建议使用中医药肾囊消肿方治疗,中药治疗多囊肾遵循整体观,可以控制调理消肿,从而彻底治愈肾囊肿。

2016年10月16日星期日

NGAL


NGAL检测的作用:NGAL( neutrophil gelatinaseassociated lipocalin)中文翻译为“中性粒细胞明胶酶相关脂质运载蛋白”,是人脂质运载蛋白家族中的一个新成员,是近年来新发现的一种早期肾损伤诊断的标志物。在急性肾功能损伤时,血、尿NGAL浓度通常会迅速升高,2 小时即可比临界值升高几十至几百倍,较目前常用的传统指标血清肌酐、尿酶等能够更早地发现肾功能损伤。在慢性肾病患者中,血清中NGAL的水平与肾小球滤过率成负相关,与血肌酐相比,NGAL能更好地反应肾小球滤过率的水平,对于早期发现、早期治疗慢性肾脏病是一个敏感、无创、特异性高的生物学指标。例如IgA 肾病是最常见的一种以原发性肾小球损伤伴小管间质改变为特征的肾小球肾炎, 其小管间质性损伤在疾病发展过程中起了重要作用,尿NGAL能够较目前临床上常用尿NAG更早地反映肾病小管间质损伤。在狼疮肾病患者中尿NGAL是优于抗dsDNA 抗体滴度的狼疮肾病诊断指标,是狼疮肾病活动性的可靠的预测因子。在药物损伤导致的慢性小管间质性肾炎中,尿NGAL优于尿mAlb,α1-MG 等标志物,能更好地反映肾功能损伤程度。在常染色体显性多囊肾病中,检测尿NGAL 浓度能够评估肾脏病变严重程度。在2型糖尿病肾病患者中血清和尿中NGAL水平明显升高,且对疾病的进展非常敏感,有助于早期评价糖尿病肾病患者的肾功能。NGAL还是较好的肾脏疾病的疗效指标,可以反映血管球性肾炎等肾脏疾病的临床疗效。
我们的优势:早期NGAL的检测多采用ELISA法,手工操作影响因素多,不适合大量样本的检测,石家庄肾病医院于2012年初在国内外率先采用美国雅培公司生产的Architect i1000SR 全自动免疫分析仪运用化学发光免疫法测定尿液NGAL,具有全自动程度高、标本容易留取、标本不需手工前处理过程、所需标本量少、可批量测定等优点,更重要的是经过大量的样本检测证实其测定量结果速度快准确高。


Function of NGAL test: NGAL;neutrpphil geatinaseassociated lipocalin, it is a new member in lipid carrier protein family, it is a sign of earlier kidney damage founded in recent years. When the acute kidney function damage, blood and urine NGAL concentration will go up, it can go up to tens and hundreds times than critical value in 2 hours. Compared with traditional index of serum creatinine and urinary enzymes,It can find renal damage earlier. In chronic kidney disease patients, NGAL level in serum blood and glomerular filtration rate is negative correlation. Compared with serum creatinine, NGAL can reflect the level of glomerular filtration rate. It is a biological indicator with features as sensitive, no wound and high specificity for chronic kidney disease early found, early treatment. For example, IgA nephropathy is the most common glomerular nephritis with featured as primary glomerular injury with tubular interstitial change, its tubule interstitial damage effects the disease development. NGAL can reflect on kidney tubule interstitial damage earlier in clinical. In lupus nephropathy patients, NGAL is better than anti-dsDNA on antibody titer in diagnosis indexes. It is an reversible predictive factor for lupus nephropathy activity. Chronic tubules interstitial nephritis caused by medicine damage, urine NGAL is better than mAlb,α1-MG and so on. It can reflect on kidney function damage degree. In Autosomal dominant polycystic kidney disease, checking up urine NGAL can assess kidney lesion degree. In the 2 style diabetic nephropathy patients, serum blood and urine NGAL level go up obviously, and they are sensitive to disease development, which is good to assess diabetic nephropathy patients kidney function. NGAL is also a better curative effects index of kidney disease, it can reflect kidney diseases clinical curative effects.
Our advantage: earlier NGAL test adopt to ELISA, manufacture operation influence is more, it is not adapt to test of amounts samples. Shijiazhuang kidney disease hospital in early 2012, pioneered in the United States at home and abroad abbott production Architecti1000SR full automatic immune NGAL urine analyzer using chemiluminescence immune analysis, has the automatic degree is high, easy to return, the specimens were not need manual pretreatment process, the required samples quantity is little and can batch determination, more important is through a large number of sample check results confirmed its determination in high speed accurately.       

降钙素原 PCT(procalcitonin)


肾脏病患者由于免疫功能异常、机体抵抗力下降、免疫抑制剂和激素的使用或糖尿病等的存在,各种感染的发生率明显高于一般人群。感染是导致肾功能衰竭患者肾功能变化的常见原因之一,是导致肾功能衰竭患者死亡的第二位原因。早期诊断感染的存在并积极的治疗至关重要。降钙素原(PCT)是降钙素的前体,细菌感染后机体多种细胞均可产生PCT而使血液中PCT升高。PCT量化反映细菌感染的严重程度和疾病的进展,早期反映抗生素治疗的疗效,并有利于指导临床选择敏感抗生素。
我们的优势:石家庄肾病医院采用德国罗氏E602电化学发光分析仪,配以原研的高质量的PCT检测试剂,较其他方法相比,实现了自动化,且灵敏度和特异性明显升高。

Kinds of infection rate of kidney disease patients is higher than normal people for  immune function abnormal, resistance declination, immunosuppressor and hormone usage and diabetes existence. Infection is one of the common reason of it is also the second factor of causing to dead of kidney failure patients. Diagnosing inflammation in the early stage and give active treatment is important. PCT is the base of reduce calcitonin, kinds of cells can produce PCT after  bacterial infection so that cause to PCT level increasing in the blood. PCT quantification reflect on the severity of bacterial infection and development of disease, reflect on the curative effects of antibiotic and is good to guide clinical choice of allergic antibiotic.
Our advantage: compared with other hospitals, Shijiazhuang Kidney Disease Hospital achieve automation and sensitivity and specificity have obvious elevation. 

补体系列检测 Alexion series test


补体系列检测的作用:抗体介导的免疫损伤是肾小球损伤的重要机制,这一机制主要通过补体和白细胞介导的途径发挥作用。补体可以通过多种机制引起肾小球损伤,补体成份的降低表示补体系统被激活,是肾病活动的重要指标之一。用于某些肾脏病的诊断和评估。
我们的优势:石家庄肾病医院经过多年研究和总结,采用德国罗氏C702全自动生化分析仪配合德国DADE BEHRING BNII 特定蛋白分析仪,配以高质量的进口试剂及国内专利试剂,较传统的补体C3C4检测更全面,能较为全面地检测补体经典途径和旁路途径的激活,对肾脏病的断和评估提供了支持。

Function of complement series test:  Antibody mediated immune injury is an important mechanism of glomerular injury. This mechanism take effects by complement and white cells mediation. Alexin can cause to glomerular injury through kinds of mechanisms, alexin composition reduction shows that alexin composition was activated, is one of the most important index of kidney disease condition, it is used as assessment and diagnosis of some kidney diseases.
Our advantages: through years of research and conclusion, Shijiazhuang Kidney Disease Hospital Adopt Germany roche C702 automatic biochemical analyzer with Germany DADEBEHRINGBNII specific protein analyzer, with high quality imported reagent and domestic patent reagent, compared with the traditional C3 and C4, it is more comprehensive and can fully test the activation of alexin classic way and bypass way, it helps to diagnosis and assessment kidney disease. 

为什么要检测淋巴细胞亚群? lymphocyte subpopulation test time


现代研究证实,几乎所有的肾小球疾病都有免疫学机制参与。淋巴细胞亚群是构成机体免疫系统的重要因素,淋巴细胞亚群数目和功能的检测是判断机体免疫功能的重要指标。患者免疫状态评估、自身免疫性肾病、免疫抑制剂治疗的时机选择和药物剂量调整等都离不开免疫功能的监测。淋巴细胞亚群的测定,主要用于评估患者机体的免疫功能是否处于平衡状态。某种细胞亚群所占百分比过高或过低,都提示存在免疫功能紊乱。
我们的优势:石家庄肾病医院采用美国BD公司的BDFACSCanto流式细胞仪,配以BD原厂抗体的绝对计数管,采对绝对计数法计数人体淋巴细胞亚群,经过近2万人份的检测,较传统的相对计数结果更准确、快速。

Why we should check up lymphocyte subpopulation?
It has been proved that immune mechanism participate in almost all glomerular disease. Lymphocyte subpopulation is an important factor of forming immune system, number and function test of lymphocyte subpopulation is an important indexes judging immunity. Patients immune condition assessment, immunity kidney disease, time choice and dosage adjust need immune function test. Lymphocyte subpopulations measurement, mainly used in assessing whether immune function is in balance or not. Too high or too low of percent of certain lymphocyte subpopulation, all shows immune function disorder.
Our advantage: Shijiazhuang kidney disease hospital in U.S. BDFACSCanto flow cytometry of BD company and factory antibodies with BD counter absolutely, mining of absolute counting method of human lymphocyte subsets, with nearly 20000 doses of the test, compared with the traditional relative count results,it is more accurate and fast.



5.狼疮系列检测 lupus series test


狼疮性肾炎是系统性红斑狼疮引发的肾脏损害。在我国狼疮性肾炎是最常见的继发性肾小球肾炎,及早诊断及早治疗极其重要。狼疮性肾炎的临床症状差异较大,轻者可无症状,需要详细的检验检查才能发现。
我们的优势:石家庄肾病医院采用德国euroimmun检测试剂盒,同时检测血液多种免疫指标,能够全面判断发病状况,配合淋巴细胞亚群检测,更有利于明确的诊断,选择合理化治疗方案。经过十多年的发展,该项检测技术成熟度高,结果准确。

Lupus nephritis is kidney damage caused by systemic lupus. In our country, lupus nephritis is the most common secondary glomerular nephritis, it is important to diagnose and treat earlier. Clinical symptoms of lupus nephritis is different, light is no symptom, it cam be found by specific detail test.
Our advantage: Shijiazhuang Kidney Disease Hospital can test kinds of immune index at the same time, and it can judge onset condition fully, it would be better to diagnose and choose right treatment plan with The lymphocyte subgroup detection. Through years of development, this test skill is experienced, the result is more accurate.








1.PLA2R(判断是否为膜性肾病) PLA2R (membranous nephropathy)


PLA2R(抗磷脂酶A2受体抗体)检测的作用:膜性肾病是导致成人肾病综合征的一个常见病因。西方国家膜性肾病约占原发性肾小球肾炎的30%,近年来国内报道膜性肾病发病率逐渐升高。膜性肾病起病往往较隐匿,以往主要依靠病理学诊断,对患者压力大,且与疾病的严重性或疗效无关。2009年膜性肾病的自身免疫学机制被发现,抗PLA2R成为特发性膜性肾病的特异性诊断指标,特异性高达特异性为98%100%,且具有less,费用低,同时对患者压力小等优点。血清抗PLA2R的滴度的升高、减少或消失等结果可评估临床情况以及治疗措施是否成功。
我们的优势:石家庄肾病医院从2013年起应用德国欧蒙欧蒙生物技术有限公司试剂在国内较早的开展了抗PLA2R检测,经过大量的样本检测,技术成熟,结果准确可靠,对特发性膜性肾病的诊断起到了很好的作用。

Function of PLA2R: membranous is a common reason of causing to adult nephrotic syndrome. Membranous disease in western occupied 30% in primary glomerular nephritis. Onset of membranous often is latent, it was diagnosed by pathology, patient had high pressure and it has no matter with illness condition severity and curative effects. Immunological mechanisms of membranous was found in 2009, anti-PLA2R became the specificity of diagnostic indicators of Idiopathic membranous nephropathy, its specificity is as high as 98%-100%, it has the advantage of less time consuming, low cost and little pressure. Titer of blood serum anti-PLA2Rs increasing, decreasing or disappear can assess clinical condition and whether treatment measures success or not.
Our advantage: Shijiazhuang Kidney Disease Hospital apply to anti-PLA2R earlier, through amounts of tests on samples, its skills are experienced, the result is more accurate, has a good function for diagnosing membranous nephropathy.

为什么要进行药物浓度检测?Why we do medicine concentration test?


任何药物都具有两重性,既能治病,也能致病。传统的给药方法是参照药物说书推荐的剂量给药,但因存在个体差异,相同的给药剂量在不同的个体间会有不同药物浓度。对那些药物安全浓度范围窄的药物而言,传统的经验用药可能会导致仅有一部分患者得到应有的疗效,而部分患者因药物浓度过低而未能达到预期的疗效,部分患者可能因药物深度过高而出现毒性作用。近年来在肾脏病治疗上取得较好疗效的多种免疫抑制类药物如环孢霉素、他克莫司(普乐可复)、雷帕霉素(西罗莫司)等都属于该类药物,无论剂量高低都可能出现不良反应。为了使药物达到最佳的疗效和最低的毒副作用,必须以检测各自血液中的药物浓度为依据,来调整用药方案,以得到好的疗效。
我们的优势:石家庄肾病医院采用国际先进的微粒子化学发光法,配以美国Abbott ARCHITECT i1000SR全自动免疫分析仪,经过多年检测,技术成熟,结果准确快速。
Duality, any drug can cure, also can cause disease.The traditional dosing method is reference to the dose of drug storyteller recommended, but due to individual differences, the same dose between different individuals have different drug concentrations.For those drugs with narrow safe concentration range, the experience of the traditional drug use may result in only part of patients get  curative effect, and some patients because drug concentration is too low and failed to achieve the desired effect and toxicity of some patients may appear because the depth of the drug was too high. Immunosuppressive drugs Obtained the good curative effect in the treatment of kidney disease in recent years such as cyclosporine, tacrolimus (zyprexa compound), rapamycin (sirolimus) belong to this kind of drugs, both high and low doses might have adverse reactions.In order to make the drug to achieve the best curative effect and the minimum side effects, must be based on detection of each drug concentration in blood, to adjust the regimen, in order to get good curative effect.
Our advantage: shijiazhuang kidney disease hospital adopts international advanced micro particle chemiluminescence method, matching with the Abbott ARCHITECT i1000SR automatic immunity analyzer, after many years of testing, mature technology, results fast and accurate.

血尿定位检测是干什么的? What is Hematuria positioning detection?


血尿是指离心沉淀尿中每高倍镜视野3个红细胞血尿并不是一个疾病的名称,而是临床上常见的一种症状或体症。它既可以由肾脏疾病引起,也可以是某些内科疾病甚至全身性疾病的重要临床表现之一。区别肾性血尿和非肾性血尿,对于肾脏疾病的诊断和鉴别诊断具有极其重要的作用,传统的尿三杯实验和红细胞变形率检测,灵敏度差,特异性低,不能很好地区分肾性血尿和非肾性血尿。
我们的优势:石家庄肾病医院经过十多年的研究,应用超高倍速相差显微镜、荧光显微镜、特蛋白分析仪、流式尿有形成份分析仪,采用特殊染色法、流式细胞法、免疫荧光法、特定蛋白分析法及相差显微镜人工镜检法,多方法联合检测,区分血尿来源,显著提高准确性。

 Hematuria refers to the in the centrifugal precipitate urine, each high power lens field of vision >= three red blood cells. Blood urine is not a kind of disease, it is the most common symptom in clinical. It can not only caused by kidney disease, but also one of important clinical manifestations in systemic disease or internal disease. It is important to kidney disease diagnosis and identify to tell kidney disease hematuria and non kidney disease hematuria. Traditional urinary three cups test and red cells deformation rate test shows its bad sensitivity and low specificity, it can not tell renal hematuria and non-renal hematuria.
Our advantage: Shijiazhuang kidney disease hospital after more than ten years of research, improving the accuracy by applying ultra-high times the speed of phase contrast microscope, fluorescence microscope, special protein analyzer, streaming urine tangible composition analyzer, the use of special staining and flow cytometry, immunofluorescence, specific protein analysis and phase contrast microscope artificial microscopy method, the method for joint detection, to distinguish the source of hematuria, significantly improve the accuracy.


PTH(甲状旁腺激素)1-84 PTH (parathyroid hormone). 1-84


慢性肾脏病-矿物质和骨异常是由于慢性肾脏病导致的矿物质及骨代谢异常综合征,是慢性肾脏病最常见的并发病之一。甲状旁腺激素是评估慢性肾脏病-矿物质和骨异常的重要指标之一。甲状旁腺激素是一种含84个氨基酸的多肽激素,在血循环中以四种形式存在:全段PTH(1-84 PTH)、氨基端片段PTH、中间段PTH及羧基端片段PTH,后二者无生物学活性。PTH检测的主要困难在于片段PTH的存在,尤其是在CKD患者中,片段PTH的存在使不同的PTH检测方法出现不同的结果。
目前常用的全段PTH(iPTH)检测时际上包含1-84 PTH和7-84 PTH两种片段,而7-84 PTH的存在使检测结果并不准确。
我们的优势:石家庄肾病医院采用德国罗氏第三代PTH检测技术检测真正的1-84氨基酸全长PTH分子。比iPTH检测值有更加准确的临床应用。CHOICE研究发现,1-84 PTH升高和透析患者死亡率增加有关,而iPTH则无统计学意义。


Chronic kidney disease-mineral and bone abnormality is due to mineral and bone metabolism syndrome of chronic kidney disease , which is one of the most common complications of chronic kidney disease. Parathyroid hormone is evaluation of chronic kidney disease (CKD) - one of the important indexes of mineral and bone abnormalities. Parathyroid hormone is a kind of containing 84 amino acid polypeptide hormones in the blood circulation exist in four forms: segment PTH (1-84 (PTH), amino end segment PTH, the middle period of PTH and carboxyl end pieces PTH, after the two no biological activities.PTH testing the main segments of the difficulty is that the existence of PTH, especially in patients with chronic kidney disease (CKD), fragments of PTH exist different PTH detection method appeared different results.
At present commonly used the entire section of PTH (iPTH) detection in the containing PTH and 7-1-84 84 PTH two fragments, and the existence of 7-84 PTH testing results are not accurate.

Our advantage: shijiazhuang kidney disease hospital adopts Germany roche's third generation of PTH detecting technology in real 1-84 amino acid molecules span PTH.Are more accurate than iPTH values in clinical application.CHOICE, the study found elevated PTH and 1-84 dialysis patients is associated with increased mortality, and iPTH, no statistical signifi

尿蛋白组分检测Urinary protein component test


尿蛋白组分检测的作用:尿蛋白不仅是慢性肾脏病的诊断和判断预后的重要指标,更是慢性肾脏病的重要进展因素。在中国大部分的慢性肾脏病患者是因蛋白尿而被诊断的。但单纯尿总蛋白定量的多少有时不一定完全反应肾脏损伤程度,即有些患者使尿蛋白含量很低,可能肾损伤已不局限于肾小球,已累及肾小管,有些患者虽然尿蛋白含量高得很,但病变局限于肾小球,因此,仅常规的尿蛋白定量有时会严重低估肾脏损伤程度,而且无法鉴别肾损伤部位。
我们的优势:石家庄肾病医院综合国内外技术,采用德国罗氏COBAS 8000生化免疫模块化分析系统联合德国西门子BNⅡ特定蛋白分析仪,配以原厂配套的高质量试剂,通过对15种尿蛋白和非蛋白氮类物质的定量分析,不仅可以更早期诊断肾脏是否有损伤,并且能区分是肾小球损伤还是肾小管损伤,损伤的程度如何,是目前国内较为全面的尿蛋白检测。

Function of urinary protein component test: proteinuria is not only an important index of diagnosis and prognosis judgment, but also a chronic kidney disease factor. In China, most of kidney disease is diagnosed by proteinuria, but simply urine protein quantitation don’t reflect totally the kidney damage degree, some patients urine protein containing is low, might kidney disease not just limited in glomerular and has damaged kidney tubules, while some patients though the protein containing is high, but lesion limited in glomerular area. Therefore, just regular urine protein quantitation would underestimate the kidney damage degree, and it can’t be sure the specific kidney damage area.
Our advantage: Shijiazhuang kidney disease hospital synthesis technology at home and abroad, modular immunized with Germany roche COBAS 8000 biochemical analysis system united Germany Siemens BN Ⅱ specific protein analyzer, with original factory supporting high quality reagents, through 15 kinds of urine protein and nonprotein nitrogen is a class of quantitative analysis, not only can be earlier diagnose kidney damage, and can distinguish glomerular damage and renal tubular damage, the extent of the damage, it is the most comprehensive proteinuria detection in domistic.




2016年10月12日星期三

Why kidney disease patients have symptoms like high creatinine?


Take an example, like a sewer, wastes and toxins produced in our body are discharged out by kidney, creatinine as a metabolic product of micro-molecule, it can be discharged smoothly by urine. So we take it as an important index measuring kidney detoxification ability. Kidney compensatory ability is strong, it is meaning that only 25% kidney unit and kidney cells can guarantee the detoxification need, the level of creatinine also can keep in the normal range, once creatinine level goes up, which shows that there are over 75% kidney units and kidney cells has been damaged seriously, it can not detoxificate normally, or the sewer is blocked by sewer, and it will be more and more serious until it cant flow. 

Why will get Diabetic nephropathy?

Diabetic nephropathy is mainly caused by primary and secondary lesions (including genetic and environmental factors, the relative or absolute lack of insulin, and resistance to insulin, high blood sugar level and metabolic syndrome), together with the disorders in immune regulation of the body, the blood sugar level will be raised and a series of pathological changes will happen to the glomerular inherent cells.The pathological changes normally lead to thickened glomerular basement membrane and narrowed lumen and blood vessel which cause disorders in blood vessel microcirculation, renal ischemia and hypoxia and damages to the blood capillary around the glomerulus and kidney tubules. Together with further inflammatory infiltration, the renal fibrosis will be triggered. Once the renal fibrosis is triggered, phenotypic switches will occur in the kidney inherent cells, large amount of extracellular matrix will be produced which could replace the healthy kidney inherent cells. With the progression of the condition, glomerular sclerosis and necrosis will come to existence. That’s why we refer it as a disease of diabetic glomerular basement membrane.  

The Causes for PKD



1. Congenital dysplasia
Congenital dysplasia can cause many kinds of disease, but for the patients with PKD, there is no change in the gene. 

2. Various of infections

The infection can cause environment changed in the body, which will enhance the activity of cyst gene, and thus cyst grows up quickly. Infection of any part on body can go into the kidneys through the blood and affect the cysts, and the infection will cause great damage to the kidney function.

3. Toxins
If there is a toxin come  into the body, various of organ injury will be caused, which  can even threaten the life.

4. Diets
Unreasonable diet can hurt our stomach easily and cause blood disorder; the healthy diet will cause gastrointestinal diseases, even with a serious poisoning; the cold diet can damage our spleen and stomach easily; the hot diets can cause gastrointestinal heat accumulation.

If he/she is on dialysis and what kind of dialysis (hemodialysis or peritoneal dialysis)

If he/she has had a kidney transplant.
Your dietitian will help you and your child understand why changes are needed and how to make the changes. It is important to work closely with your child’s dietitian. Because your child’s appetite may change throughout the course of kidney failure, it is important to remember that understanding and patience provide the best chance of success at meal time.
The nutrients most often affected in kidney disease are:
Sodium Potassium
Phosphorus Protein
Calories Fluid
Balancing these nutrients in a healthy diet can be confusing at first. Not all nutrients need to be changed at once. As kidney function decreases, the diet 

How to Detect Symptoms of Avascular Necrosis

Avascular necrosis is a condition in which blood supply to the bone is lost leading to bone cell death, collapse, bone destruction, and may even lead to eventual joint dysfunction. The hip is the most common site of avascular necrosis, though it can attack any bone or joint. The only real symptom is pain. While avascular necrosis doesn't seem threatening from the outset, if left untreated, it can become very serious – in fact, at the first sign of bone pain, you should visit your doctor.[1] However, starting with Step 1 below, you can detect the symptoms and put a stop to it before serious treatment is necessary.
Know that stabbing, shooting pain is the only major symptom. As the bone or joint is breaking down, it will manifest as sharp pains that are often described as stabbing, shooting, tearing or piercing. If you have AVN in your hip, this pain will be more focused in the groin, thigh and buttocks.
Know you'll feel more pain if you put weight or pressure on the bone. And as the condition progresses or gets worse, pain may occur even if you are lying down or resting. With pressure on the bone or joint, you may also experience stiffness and muscle spasms.
· Severe pain is described as such when it interferes or limits your joint function or activity. This, unfortunately, means this joint is already collapsing or breaking down.
Know that the pain will only get worse if left untreated. The progression of AVN may take months to a year. The pain may intensify from mild to severe if it is left untreated. There is no way to determine how often the pain will occur. The only thing you can expect is more pain more often if you continue to do things involving the damaged area.

· Stiffness and muscle spasms, too, will likely occur more often as the muscles from the damaged area lose support from the bones. The veins in the muscles, for the record, are highly affected as well because of decreased blood flow.

These Foods Are Suitable for PKD Patients

1. Vegetables and fruits rich in vitamin
2.Vegetables and fruits rich in iron, such as carrot and so on.
3.Vegetable produce dissolving stones, such as black fungus and so on.
4. The foods with diuretic effect.5.Alkaline food is also advised to be taken, which plays a supplementary role in the treatment.
 

High uric acid hematic disease diet attention

Reasonable diet can effectively alleviate high blood uric acid and gout disease. What issues should pay attention to on the diet for Such patients?
1 To maintain ideal weight.Keep weight in ideal BMI = 20 ~ 25, slowly lose weight, a month with weight loss 1 ~ 2 kg advisable, but should not be weight loss when acute disease onset of.Losing weight too fast can cause tissue decomposition, resulting in the production of a large number of uric acid, acute gout attack.
2 Protein intake moderation.Dinner, dinner parties and overeating, are easy to excess protein.
3 No Diet foods high in purine.Such as animal offal, thick gravy, bone marrow, seashells, sea crab, anchovies, sardines, cod, eels, roe, etc.Shrimp, meat, peas, spinach also contains a certain amount of purine, so can't eat more.
4 To reduce oil intake.Can convert steaming, boiling, halogen, cold way of cooking.
5 Drink more water.Enough water can make uric acid excretion, high uric acid hematic disease, every day to drink at least 2500 ~ 3000 ml water.Consider the specific condition in patients adjusting to drink water.
6 Avoid alcohol, including beer.Beer contains a large number of purine, alcohol can make uric acid synthesis.
7 eat some more high potassium foods.Such as bananas, broccoli, celery, etc., potassium can decrease uric acid precipitation, help to uric acid excretion.Diet therapy create the good environment for the treatment of patients with high uric acid hematic disease, must not ignore the role of diet in the treatment.
Hyperlipidemia matters needing attention
1 Limit high-fat foods: strictly choose low cholesterol food, such as vegetables, bean products, lean meat, jellyfish, especially eat more fiber vegetables, can reduce the intestinal absorption of cholesterol.But, not one-sided emphasis on high fat intake, because some essential fatty acids in the diet can be beneficial to the body.
2 Change the way of cooking, cooking oil drain less, as far as possible with steamed, boiled, cool cook.Eat less Fried foods.
3 Limit sweets: sugar can be conerted to endogenous triglycerides in the liver, the higher concentration of triglycerides in the blood plasma, so should limit the intake of sweets.
4 Loss weight: the people weight more than normal, should be under the guidance of gradually lose weight, loss weight per month on a 1 ~ 2 kg is advisable.Weight reduction diet principle is low fat, low sugar, enough protein.
5 Strengthen physical activity: physical activity can not only increase the consumption of thermal energy, but also can enhance the body's metabolism, improve some enzymes in the body, especially the activity of lipoprotein lipase, is conducive to the transport and decomposition of triglycerides, reducing blood lipid.
6 Give up smoking, drinking less, drinking a moderate amount can make the serum high density lipoprotein LDL levels.Therefore, moderate drinking can decrease the prevalence of coronary heart disease (CHD).Alcohol or drinking for a long time, can stimulate the liver synthetic more endogenous triglycerides, increase the blood concentration of low density lipoprotein hypercholesterolemia.Therefore, middle-aged better not drinking. Smokers’incidence of coronary heart disease and mortality are 2 ~ 6 times of non-smokers, and daily count would inprove with smoking.
7 Avoid excessive tension: emotional tension, excessive excitement, can cause increased blood cholesterol and triglyceride levels.All have this kind of situation, can use small doses of sedatives (in accordance with the doctor's advice).
8: Drug treatment by the above method is still can't control should be combined with drug treatment of hyperlipidemia patients.Drugs of choice, please after consulting a professional doctor, choice by the doctor according to the specific etiology.

2016年10月9日星期日

How to eliminate edema

         
For the pathogenesis of timely treatment, The principle is as follows:

1. Limiting sodium intake: Nephritis edema or kidney disease has sodium water retention,all need to limit sodium intake.But also are appropriate,it is very easy can cause hyponatremia if limit sodium for a long time;
2. Diuresis: If it is necessary,at the same time to limit sodium,with taking diuresis, which it not only can promote the sodium water remove out to relieve edema,but also can relieve high blood pressure and lighten heart load;
3. Control proteinuria: For nephrotic edema must control proteinuria. It can use immunosuppressant (hexadecadrol, prednison) to restore glomerular normal permeability;
4. Plasma protein supplement:Edema is caused by kidney damage.So the fundamental treatment is for the cause of the kidney.

Warm prompt:
Red Bean  With very rich potassium.But the saponin in the cortex has a very strong diuretic effects. It will have the effect for the face and foot edema caused by beriberi and Kidney function decline if make it red bean soup.

Watermelon  It has a good diuretic effect,which is also one of the medicine for kidney disease.

Cucumber  Can eat raw with peel,it also can dry attached the melon and vines with boiled water to drink,which have the much stronger diuretic effect.But,it is not suitable for people who gastrointestinal is very cold to take more raw cucumber.